The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus

INTRODUCTION Amyloid plaque has been reported in brain biopsies from patients with idiopathic normal-pressure hydrocephalus (iNPH) and proposed as a significant feature of the pathophysiology. Presence of the apolipoprotein E ε4 (APOE ε4) allele is associated with increased risk of Alzheimer's disease (AD). AIMS To compare the distribution of APOE genotype in iNPH patients with an age-matched...

متن کامل

Idiopathic Normal Pressure Hydrocephalus

Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurodegenerative disease commonly characterized by a triad of dementia, gait, and urinary disturbance. Advancements in diagnosis and treatment have aided in properly identifying and improving symptoms in patients. However, a large proportion of iNPH patients remain either undiagnosed or misdiagnosed. Using PubMed searc...

متن کامل

Idiopathic normal pressure hydrocephalus in neurological practice

Background: We have previously seen that idiopathic normal pressure hydrocephalus (iNPH) patients havingelevated intracranial pressure (ICP) pulse amplitude consistently respond to shunt surgery. In this study weexplored how the cerebrospinal fluid pressure (CSFP) pulse amplitude determined during lumbar infusion testing,correlates with ICP pulse amplitude determined during over-nig...

متن کامل

Glymphatic MRI in idiopathic normal pressure hydrocephalus

The glymphatic system has in previous studies been shown as fundamental to clearance of waste metabolites from the brain interstitial space, and is proposed to be instrumental in normal ageing and brain pathology such as Alzheimer's disease and brain trauma. Assessment of glymphatic function using magnetic resonance imaging with intrathecal contrast agent as a cerebrospinal fluid tracer has so ...

متن کامل

Is normal pressure hydrocephalus becoming less idiopathic?

Normal pressure hydrocephalus (NPH) has posed a challenge to neurologists for 5 decades. Difficulties in understanding its pathophysiology have hindered efforts to diagnose it and to develop a better approach to selecting patients for shunt surgery. We know that many patients with NPH have CSF absorption difficulty as measured by resistance to CSF outflow (Rout). The problem is that many with n...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: PLOS ONE

سال: 2016

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0158985